The Ohio River runs from the Appalachian Mountains and foothills across the Midwest to empty into the Mississippi.
Originating in Wyoming and "snaking" across the Pacific Northwest, the Snake River is the largest tributary of the Columbia River.
The Red River of the South borders Oklahoma and Texas before flowing into the Mississippi.
The Columbia River originates in the Canadian Rockies and works its way southwest to form the Washington-Oregon border before emptying into the Pacific.
The Arkansas River, a significant Mississippi tributary, has three portions. Its mountain origins in central Colorado provide great whitewater rafting.
The Colorado River has figured large in the news in recent years as California and much of the rest of the Southwest have endured a decades-long drought.
Originating in the Colorado Rockies, the Rio Grande flows southeast to the Gulf of Mexico, forming the border between Texas and Mexico along most of its length.
As promised, we included one massively long American river in this list with no snakes to give a welcome reprieve to those who fear them.